Reverse Engineering the source code of the BioNTech/Pfizer SARS-CoV-2 Vaccine

https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/

• The CAP to make sure the RNA looks like regular mRNA
• A known successful and optimized 5' untranslated region (UTR)
• A codon optimized signal peptide to send the Spike protein to the right place (amino acids copied 100% from the original virus)
• A codon optimized version of the original spike, with two ‘Proline’ substitutions to make sure the protein appears in the right form
• A known successful and optimized 3' untranslated region
• A poly-A tail with a ‘linker’ in there

 

If we look closely, we see that the majority of the changes happen in the third codon position, noted with a ‘3’ above. And if we check the universal codon table, we see that this third position indeed often does not matter for which amino acid is produced.

So, the changes are synonymous, but then why are they there? Looking closely, we see that all changes except one lead to more C and Gs.

So why would you do that? As noted above, our immune system takes a very dim view of ‘exogenous’ RNA, RNA code coming from outside the cell. To evade detection, the ‘U’ in the RNA was already replaced by a Ψ.

However, it turns out that RNA with a higher amount of Gs and Cs is also converted more efficiently into proteins,

And this has been achieved in the vaccine RNA by replacing many characters with Gs and Cs wherever this was possible.

This is one of the exceptionally clever bits about the vaccine. Our body runs a powerful antivirus system (“the original one”). For this reason, cells are extremely unenthusiastic about foreign RNA and try very hard to destroy it before it does anything.

This is somewhat of a problem for our vaccine - it needs to sneak past our immune system. Over many years of experimentation, it was found that if the U in RNA is replaced by a slightly modified molecule, our immune system loses interest. For real.

So in the BioNTech/Pfizer vaccine, every U has been replaced by 1-methyl-3'-pseudouridylyl, denoted by Ψ. The really clever bit is that although this replacement Ψ placates (calms) our immune system, it is accepted as a normal U by relevant parts of the cell.

Many people have asked, could viruses also use the Ψ technique to beat our immune systems? In short, this is extremely unlikely. Life simply does not have the machinery to build 1-methyl-3'-pseudouridylyl nucleotides. Viruses rely on the machinery of life to reproduce themselves, and this facility is simply not there. The mRNA vaccines quickly degrade in the human body, and there is no possibility of the Ψ-modified RNA replicating with the Ψ still in there. “No, Really, mRNA Vaccines Are Not Going To Affect Your DNA” is also a good read.

Lauren Groff - "Matrix"

"Matrix" for the Latin for Mother.

One of those exceptional books that tell the whole lifetime of a character and you actually believe it. Marie de France, unknown who she was according to wikipedia, but so influential in the 12th century....

But Goda needs to punish someone, and so the grave is dug in the unconsecrated ground outside the churchyard, without ceremony, Avice is lowered into it in her shroud facedown with her babe at her feet, so that in the Revelations her bones will never be able to rise to the hands of the Angels of the Resurrection. Such pitilessness, Marie thinks, for a sin of flesh.

At last, she shees a clump of darkness on a rise that, when Marie nears, revels the sheep saved, nuns running into the sodden fields waist deep to save more. Palenesses floating in the dark are drowned sheep. Marie wades out into the icy water to her waist, to her ribs. Cold sezies her and the wet habit grasps at her legs. She finds a ewe standing upon a dead sister, paddling with its front legs in panic, and though the beast is twice the size of an ordinary child and thashes in her frenzy, Marie picks her up in her arms and carriers her to the rise.

And her smell was strong, the soap of lemon balm and lavender at the heart of her braid, skin with honey and wild onions and leaf rot in it.

So hungry, the nun's faces are skulls skinned of flesh in the dark dortoir. There are soups in which meat is boiled and removed to save for future soups. Fingernails the cold blue of sky.